My general rule of thumb is a good smear of "Spinner Eaze" from Cobra Valley,
http://performanceunlimited.com/cobr...innereaze.html
hammer them firmly (not HARD, just firm) until they get tight, and then give it one final good whack. Safety wire and they will come off with just a couple firm whacks on opposing ears (never beat just one ear to death...spread the blows across all of them, angle permitting). Use a piece of 2x4 against the ears to impart more hammering leverage (if necessary).
The Spinner Eaze doesn't gum up as much as the typical gray Permatex anti-seize. Just put a drop on your finger and spread it over each lug, the face of the wheel hub, the hub adapter and the concentric back face on the spinner.
-Dean