Jack Roush says "Set the advance curve to be as quick as possible before the engine begins to ping during acceleration." Bill Caroll says that 10 degrees intial is good but total ignition lead over 38 degrees "will be totally dangerous". I don't know what type of cam your running or the vacuum your pulling but if you don't see a change when its hooked up I'd check the vacuum at the carb. or the vacuum canister. 45 degrees sounds like alot of advance. Good Luck........Jim