Any engine that has priority oiling to the mains is better suited to high performance (high rpm, high Hp) use. That said the side oiler is better suited to high performance use. If you keep the rpm in a reasonable range, a standard block will do.
The vast majority of people, who know what a Cobra is, are going to excitedly ask if it has a 427 in it. When you say no, you can see a tab bit of sparkle disappear from their eyes, from that disappointment. They are still interested and excited, but you can tell they would have had an orgasm on the spot, if it had had a 427 side oiler in it. Is this fact going to matter to you?
A FE is going to cost you 1.5 times the cost of a 351W based engine, more or less (most likely more). It is not hard to spend $20K on a FE. Being blatantly honest, the FE is a marvel of a horrible design, that was successful in racing. It requires much more skill to build than most engines, but is quite capable, when done right. It is a beautiful engine to see, but it is expensive and can be problematic (especially if the builder is not an expert FE guy or if you try to cut costs).
PS
How do you feel about your car pissing
oil on your garage floor? Most FE engines tend to do that.