Blykins Brent want to bet a lunch bill?
If you go back to the old days, Isky had a rev kit for FE. In todays world we will have a rev kit again. Waiting on the Jay Brown PSE manifold. All the wishes will be filled.
As for roller or solid lifers, here a list of thing to extend life of them
1 no idling of the motor
2 correct lash on the tight side. HP lost but wear and life extended
3
OIL,
OIL,
OIL, Finding the best with the most protection against wear
4 oil pressure feed pin roller lifters
5 For high spring pressures and lift camshafts, bronze bushings and .904"
lifters from dodge
6 For an FE motor, high oil pressure in the 70-85 psi hot over 2,000 rpms.
7 If you have a great machinist add oil sprayers to motor for piston cooling and pin lube.
I have done and seen some of this done to other motors that are raced, An FE SO motor was not ment to be a 100,000 mile car motor. Made to race in NASCAR and 1/4 mile.
Dimis if you have silly money build the motor any way you like with either solids or rollers. Maintainance and good oil and suppliments are what is going to give your motor and lifters longer life. Chance of going 50K with out a rebuilt is small. It is possible. You didn't say anything about HP and torque for the motor you are building. With these numbers and head flow, you will answer your own questions. Max flow of the head is what? 350 cfm at .700". Put a cam shaft in the motor with a total of rocker arm and ratio to equal .700" total. anything more and you are just wasting motor and parts.
Good luck Rick l.