IMHO a small block stroker, and not necessarily to 427in, is the way to go.
For me, there's no sweeter sound than a high revving small block cruising down the road at 3800-4000 RPM(.8 fifth). After the pipes get blown out, it's just a different car! I did that cross country twice from Az to Spring Fling and had the time of my life...even going through a toad strangler in Colo.
Now at 68 getting in and out is more of a challenge but like I told Marilyn, when I die just put some coffin handles on the sides and plant me in it!
Mike