There is no functional difference between the slab side and the 427 body styles. They essentially use the same chassis. I think the 427 body looks the best, and makes a fine cruiser.
As for nbo tinkering, it depends on what you mean by that. My car has a Coyote engine, using the stock computer. Nothing radical or trick about it - except the blower, of course. I just push the button and drive it. Change the
oil ever fall/winter.
It's not tinker proof, though. I'm always messing around with it for one reason or another.