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Jeff,
Well, I just calculated mine with the 289 and on a race weekend I am getting 2.5 mpg and the fuel that I am running is $12 per gallon!
RS, as others have pointed out, you need to take a look at the whole system. You cannot isolate one factor to account for the operation of a whole. Also, Webers are different than one or two four barrel carbs. They are not progressive like four barrels, it's all eight in all the time. A car with a four barrel will spend part of the time operating on just two barrels.
There is some great advice above. When I tuned mine we used a AFR gauge on each header tube to get the idle right and set the main jets. You probably do not need that, but have an AFR gauge on each bank as pointed out previously is a good idea.
Good luck.
Jim
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