[scottj]

Joe,
Yes the larger bore will do just that. I don't know how tough the the new Ford block is with regard to the cylinder walls but if it's like the GM aftermarket blocks it should not need to be rebored at rebuild time due to wear. My builder encouraged me to go with a 4.155 bore over 4.125 to unshroud the valves. They never have to do anything to the cylinders except a light hone at rebuild but if I did hurt it I still have a few bores left.
I use Crower's 4340 non-twist cranks, they will handle that easily with the right weight piston.
Scott

One other thing; at that rpm be prepared for yearly freshens. The valve springs might last 1000 track miles or 2000 street miles. The same with roller lifters.