Brent,
Sorry to hear that you are still having this problem. I believe you said in an earlier post that you have replaced all of the valve train components with brand new stuff. Rocker arms & etc. Like Ernie said, it is hard to imagine 16 bad new lifters and a cam would not normally wear off the same on all lobes. However since this seems to be turning into the motor from he--, I am not sure what I would do next. I like 427/SOs idea but if this keeps happening maybe an exorcism. You never changed heads and cam did you ? Have you talked to George Anderson or Tom Lucas about this ? One other thought and this is really reaching. Have you checked the height of your valve springs and their strength before installing and then after running them for a while. Could they be compressing just a little bit and binding at all after getting hot ? Just a wild guess here but the way things have gone I wouldn't be surprised at anything you find. I am sure that after all of this you have checked the oiling system completely and have plenty of
oil. I don't remember, are you using roller rockers and lifters ? If this happens again in a few miles what about taking a lifter out and looking at it to see it it shows any strange markings.
Ron