I start with a nice Windsor block and trade it in for a good used 460 block. Stroke it to 521, add the Kasse engineered SCJ heads and a nice roller cam. Dual plane single carb manifold with a 1000 CFM carb. Have a nice easy 500 - 550 + HP and Torque at less than 6000 RPM. Set the rev limiter at 6000 so the engine just runs forever without getting stressed out or overheated.
You only said I had to start with a 351 block. You didn't say I had to end up with one.
Ducking and covering....