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Your question all depends on how your motor is designed. Low end torque, mid-range or top end performer. My 418 stroker was built as a track motor with gobs of mid range. I have a dual pattern cam with .572 on the intake and .576 on the exhaust. Heads are Edelbrock Victor Jr. with a Victor Jr. manifold topped with an 850 Holley. 750 Holleylost too much HP at top end.

If your motor is to be a cruiser with mild to moderate cam profile designed with low end power, stick with a dual plane manifold and a 750 cfm carb with vacuum secondaries.