Hi David,
If I was building a bigger engine (someday?) I'd use those heads
Here's Kaase's take on the development:
Kaase's CJ 460 head development writeup
Note that the cam profile has considerable influence, and watch out for piston to valve clearance!
As an afterthought, killing a bit of low end might be a good thing
Regards,
Tom
PS: Dunno anything about the Edelbrocks, but if you're looking around, the 385 bunch seems to like the TFS heads, too. Here's another URL:
385 Forum head flow comparison