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I run a griffin radiator and a single 16" Spal fan with a custom made aluminum shroud that seals the fan to the radiator. This setup works well. Have not ioverheated it in the Phoenix area yet and I've got 12.5:1 CR in a 427.

Use Spal fans. They are the best out there. Look at the rated CFM for the Spal fans and decide if you can fit two fans big enough to get more CFM together than the largest single you can run. This will help you decide on one vs two. I think mine is 2600 CFM.

It is also CRITICAL to put a good-sealing shroud around the fan(s). If you cannot buy one, make one like I did from .040" 5052H sheet aluminum. My 1/2 full sheet (4' X 4') cost me $12 and then about 3 days later of pattern making, folding and riveting - your ready to go.