I have the tremec 3350. here is a nifty little calcuator
http://www.secondstrike.com/Technical/GearCalc.asp
this helped me out a bunch. I have a 427 with just under 600HP and quite a bit of torque. the loss in performance has been minimal with the gear change and the change in "useful" ranges of the gears is great. I can actually use all the gears!