I'm running a 428 crank in mine, the stroke isn't 'that important'. What is of more concern is matching the cam with your expected cruise rpm (read that rear gear ratio) and heads, intake, exhaust system etc. Cam selection is one of the more tricky things to get right.
Lets say your running a 5 speed (poor misguided soul that you might be
) and your cruise rpm for your typical mph on highway is 2200 rpm. Yet your CAM profile prefers 2500 or higher rpm. You got a problem! The motor will not be happy being below the cam curve. You will find yourself speeding up or downshifting into 4th (which is what you should have anyway
).