I thought the 460 aluminum block was a dry block for racing only. If you have found a wet 460 aluminum block let me know. I will be building a new engine next Winter.
Also, you did not mention a Compression Ratio. If you are going with a boosted engine, I would limit the C/R to 7 or 7.5 to 1 and then run more boost. For the same cylinder pressures, you will get greater HP from the lower C/R setup.